Association Between KCNJ6 (GIRK2) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence

Association between KCNJ6 (GIRK2) Gene Polymorphisms and Postoperative Analgesic Requirements after Major Abdominal Surgery

Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK) channel subunit, GIRK2, that is an important molecule in opioid transmission. In our initial polymorphism search, a total...

A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size.

AIM KCNJ6 coding for potassium inwardly rectifying channels (Kir3.2, GIRK2) is important for opioid receptor transmission. The KCNJ6 rs2070995 AA genotype has been associated with increased opioid analgesic requirements in Japanese. We analyzed its consequences for other opioid effects. METHODS Genotyping was done in 85 methadone-substituted former heroin addicts, 352 opioid-treated chronic p...

Novel concepts of analgesia for post operative pain: Multimodal analgesia

Association study between schizophrenia and the DISC1 gene polymorphism

  Abstract   Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome   position 1q42, was initially identified at the breakpoint of a balanced translocation,   t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large   Scottish family.   Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia   on the basis of DSM-IV criteria an...

Close association between A118G single nucleotide polymorphism and opioid, alcohol, and nicotine dependence

Correspondence: Shailendra Kapoor 2300 E Cary Street, Richmond, VA 23223, USA Email [email protected] I read with great interest the article by Cosci et al in a recent issue of your journal. The article provides for highly interesting reading and is very thought-provoking. Interestingly, the past few years have seen the emergence of extensive data that establish a close association bet...